Laboratório de Fisiologia e Fisiopatologia Cardiovascular
martinspinge@uel.br
(43) 3371-5927Currículo
Currículo Lattes: http://lattes.cnpq.br/0791976490438294
Linha de Pesquisa
Fisiologia e Fisiopatologia cardiovascular
Descrição
O interesse do laboratório de fisiologia cardiovascular está em estudar os mecanismos de controle cardiocirculatório central e periférico em animais sob condições fisiológicas como o exercício físico e mudanças posturais, bem como em modelos animais de doenças como a obesidade, a sepse, a doença de Chagas e o parkinsonismo. Para essa abordagem utilizamos técnicas de estereotaxia; registro cardiovascular invasivo e não invasivo; análise da variabilidade cardiovascular e dosagens bioquímicas em plasma e tecidos.
Principais trabalhos
MARTINS-PINGE, M. C.; JAGER, L. ; CAMPOS, B. H. ; BEZERRA, L. O. ; TURINI, P. G. ; PINGE-FILHO, PHILENO . NITRIC OXIDE INVOLVEMENT IN CARDIOVASCULAR DYSFUNTIONS OF PARKINSON DISEASE. Frontiers in Pharmacology, v. 13, p. 898797, 2022.
LOPES, F. N. C. ; CUNHA, N. V. ; CAMPOS, B. H. ; FATTORI, V. ; PANIS, C. ; Cecchini R ; VERRI JUNIOR, W. ; PINGE-FILHO, PHILENO ; MARTINS-PINGE, M. C. . Antioxidant therapy reverses sympathetic dysfunction, oxidative stress, and hypertension in male hyperadipose rats. LIFE SCIENCES, v. 295, p. 120405, 2022.
RAQUEL, H. A. ; GUAZELLI, C. F. S. ; VERRI JR, W. A. ; Michelini LC ; MARTINS-PINGE, M. C. . Swimming training reduces iNOS expression, augments the antioxidant defense and reduces sympathetic responsiveness in the rostral ventrolateral medulla of normotensive male rats. BRAIN RESEARCH BULLETIN, v. 170, p. 225-233, 2021.
DE CAMPOS, BLENDA HYEDRA ; DE JAGER, LORENA ; REGINATO, GABRIELA SOUZA ; PEREIRA, RITO SANTO ; CRESTANI, Carlos César ; PINGE-FILHO, PHILENO ; MARTINS-PINGE, MARLI CARDOSO . Cardiovascular evaluation of female rats with 6-OHDA-induced parkinsonism: Possible protection by ovarian hormones and participation of nitric oxide. LIFE SCIENCES, v. 259, p. 118259, 2020.
TUROSSI AMORIM, ERIC DIEGO ; DE JAGER, LORENA ; MARTINS, ANDRESSA BUSETTI ; RODRIGUES, ANANDA TOTTI ; CRUZ LUCCHETTI, BRUNO FERNANDO ; ARIZA, DEBORAH ; PINGE’FILHO, PHILENO ; CRESTANI, Carlos Cesar ; UCHOA, ERNANE TORRES ; MARTINS’PINGE, MARLI CARDOSO . Glutamate and GABA neurotransmission are increased in paraventricular nucleus of hypothalamus in rats induced to 6-OHDA parkinsonism: Involvement of nNOS. ACTA PHYSIOLOGICA (ONLINE), v. 226, p. e13264, 2019.
LUCCHETTI, B. ; BOARETTO, N. ; LOPES, F. N. C. ; MALVEZI, A. D. ; LOVO-MARTINS, M. I. ; TATAKIHARA, V. ; FATTORI, V. ; PEREIRA, R. ; VERRI JUNIOR, W. ; ARAUJO, E. J. A. ; PINGE-FILHO, PHILENO ; MARTINS-PINGE, M. C. . Metabolic syndrome agravates cardiovascular, oxidative and inflammatory dysfunction during the acute phase of Trypanosoma cruzi infection in mice. Scientific Reports, v. 9, p. 18885, 2019.
DE JAGER, LORENA ; AMORIM, ERIC DIEGO TUROSSI ; LUCCHETTI, BRUNO FERNANDO CRUZ ; LOPES, FERNANDA NOVI CORTEGOSO ; CRESTANI, Carlos Cesar ; PINGE-FILHO, PHILENO ; MARTINS-PINGE, MARLI CARDOSO . Nitric oxide alterations in cardiovascular system of rats with Parkinsonism induced by 6-OHDA and submitted to previous exercise. LIFE SCIENCES, v. 204, p. 78-86, 2018.
RAQUEL, H. A. ; FERREIRA, N. Z. ; LUCCHETTI, B. ; BARNA, B. F. ; PINGE-FILHO, PHILENO ; Michelini LC ; MARTINS-PINGE, M. C. . The essential role of hypothalamic paraventricular nucleus nNOS in the modulation of autonomic control in exercised rats. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 79, p. 14-24, 2018.
PAULA, J. C. C. ; CAMPOS, B. H. ; JAGER, L. ; AMORIM, E. D. T. ; ZANLUQUI, N. ; FARIAS, C. C. ; HIGASHI, L. ; PINGE-FILHO, PHILENO ; BARBOSA, D. S. ; MARTINS-PINGE, M. C. . Effects of Inducible Nitric Oxide Synthase Inhibition on Cardiovascular Risk of Adult Endotoxemic Female Rats: Role of Estrogen. Frontiers in Physiology, v. 9, p. 1020, 2018.
CUNHA, N. V. ; LOPES, F. N. C. ; PANIS, C. ; Cecchini R ; PINGE-FILHO, PHILENO ; MARTINS-PINGE, M. C. . iNOS inhibition improves autonomic dysfunction and oxidative status in hypertensive obese rats. Clinical and Experimental Hypertension (1993, Print), v. 39, p. 50-57, 2017.
LUCCHETTI, B. ; ZANLUQUI, N. ; RAQUEL, H. A. ; LOVO-MARTINS, M. I. ; TATAKIHARA VL ; BELEM, M. O. ; Michelini LC ; ARAUJO, E. J. A. ; Pinge-Filho, P. ; MARTINS-PINGE, M. C. . Moderate treadmill exercise training improves cardiovascular and nitrergic response and resistance to Trypanosoma cruzi infection in mice. Frontiers in Physiology, v. 8, p. 315, 2017.
PAULA, J. C. C. ; CAMPOS, B. H. ; AMORIM, E. D. T. ; SILVA, R. V. ; FARIAS, C. C. ; HIGASHI, L. ; Pinge-Filho, P. ; BARBOSA, D. S. ; MARTINS-PINGE, M. C. . Cardiovascular risk and the effect of nitric oxide synthase inhibition in female rats: The role of estrogen. EXPERIMENTAL GERONTOLOGY, v. 97, p. 38-48, 2017.
RAQUEL, H. A. ; MASSON, G. S. ; BARNA, B. F. ; ZANLUQUI, N. ; PINGE-FILHO, PHILENO ; Michelini LC ; MARTINS-PINGE, M. C. . SWIMMING TRAINING MODULATES NITRIC OXIDE-GLUTAMATE INTERACTION IN THE ROSTRAL VENTROLATERAL MEDULLA IN NORMOTENSIVE CONSCIOUS RATS. Frontiers in Physiology, v. 7, p. 221, 2016.
ARIZA, D. ; SISDELI, L. ; CRESTANI, Carlos Cesar ; Fazan Jr., R ; MARTINS-PINGE, M. C. . DYSAUTONOMIAS IN PARKINSON’S DISEASE: CARDIOVASCULAR CHANGES AND AUTONOMIC MODULATION IN CONSCIOUS RATS AFTER INFUSION OF BILATERAL 6-OHDA IN SUBSTANTIA NIGRA. American Journal of Physiology. Heart and Circulatory Physiology, v. 308, p. H250-H257, 2015.
Silva, AS ; ARIZA, D. ; DIAS, Daniel P M ; CRESTANI, Carlos César ; MARTINS-PINGE, M. C. . Cardiovascular and autonomic alterations in rats with parkinsonism induced by 6-OHDA and treated with L-DOPA. Life Sciences (1973), v. 127, p. 82-89, 2015.
AMORIM, E. D. T. ; PERAS, V. R. ; ANDRADE, O. ; MARTINS-PINGE, M. C. . Functional evidence of paraventricular nucleus involvement in cardiovascular and autonomic modulation in response to acute microgravity (head-down tilt) in unanesthetized rats. Journal of Neuroscience Research, v. 93, p. 1305-1312, 2015.
Ariza, D ; LOPES, F. N. C. ; CRESTANI, Carlos Cesar ; MARTINS-PINGE, MARLI CARDOSO . CHEMOREFLEX AND BAROREFLEX ALTERATIONS IN PARKINSONISM INDUCED BY 6-OHDA IN UNANESTHETIZED RATS. Neuroscience Letters (Print), v. 607, p. 77-82, 2015.
CUNHA, N. V. ; Pinge-Filho, P. ; PANIS, C. ; SILVA, B. R. ; PERMONIAN, L. ; GRANDO, M. D. ; Cecchini R ; BENDHACK, L. M. ; MARTINS-PINGE, M. C. . DECREASED ENDOTHELIAL NITRIC OXIDE, SYSTEMIC OXIDATIVE STRESS AND INCREASED SYMPATHETIC MODULATION CONTRIBUTE TO HYPERTENSION IN OBESE RATS. American Journal of Physiology. Heart and Circulatory Physiology, v. 306, p. H1472-H1480, 2014.
de Andrade, Ozahyr ; BORGHI, SERGIO MARQUES ; de Souza, Hugo Celso Dutra ; Fontes, Marco Antonio Peliky ; MARTINS-PINGE, MARLI CARDOSO . Paraventricular nucleus of hypothalamus participates in the sympathetic modulation and spontaneous fluctuation of baroreflex during head up tilt in unanesthetized rats. Neuroscience Letters (Print), v. 558, p. 1-7, 2014.