Laboratório de Fisiologia Metabólica
giselebertolini@uel.br
(43) 3371-5942
Currículo Lattes: http://lattes.cnpq.br/5587035486427002
Linha de Pesquisa
Fisiologia Metabólica
Descrição
No Laboratório de Fisiologia Metabólica estudamos a participação do fígado na regulação da glicemia e do metabolismo energético em diferentes condições metabólicas. Estudamos também as alterações do metabolismo de carboidratos, lipídeos e proteínas em diferentes estados patológicos, como no diabetes mellitus.
Research description:nIn the Metabolic Physiology Laboratory, we study the liver’s role in regulating blood glucose levels and energy metabolism under various metabolic conditions. We also investigate changes in carbohydrate, lipid, and protein metabolism in different pathological states, such as diabetes mellitus.
Principais trabalhos
MIKSZA, DANIELE ROMANI ; BIAZI, GIULIANA REGINA ; FRASSON, ISABELE GONÇALVES ; DE SOUZA GALIA, WINNY BEATRIZ ; FERRAZ, LAURA SOCIO ; DIAZ, BRENDA FRANCISCONI ; KURAUTI, MIRIAN AYUMI ; MARMENTINI, CARINE ; MAREZE-COSTA, CECÍLIA EDNA ; PERES, SIDNEY BARNABÉ ; CASSOLLA, PRISCILA ; BERTOLINI, GISELE LOPES ; BAZOTTE, ROBERTO BARBOSA ; DE SOUZA, HELENIR MEDRI . Insulin in combination with pioglitazone prevents advanced cachexia in 256-Walker tumor-bearing rats: effect is greater than treatment alone and is associated with improved insulin sensitivity. Pharmacological Reports, v. 75, p. 1571-1587, 2023.
BIAZI, GIULIANA R. ; UEMURA, ISABELE G. F. ; MIKSZA, DANIELE R. ; FERRAZ, LAURA S. ; DIAZ, BRENDA F. ; BERTOLINI, GISELE L. ; DE SOUZA, HELENIR M. . Interleukin 6 acutely increases gluconeogenesis and decreases the suppressive effect of insulin on cAMP-stimulated glycogenolysis in rat liver. CELL BIOCHEMISTRY AND FUNCTION, v. 41, p. 609-618, 2023.
SOUZA GALIA, WINNY BEATRIZ; BIAZI, GIULIANA REGINA; FRASSON’UEMURA, ISABELE GONÇALVES; MIKSZA, DANIELE ROMANI; ZAIA, CÁSSIA THAÏS BUSSAMRA VIEIRA; ZAIA, DIMAS AUGUSTO MOROZIN; SOUZA, HELENIR MEDRI; BERTOLINI, GISELE LOPES. Gluconeogenesis is reduced from alanine, lactate and pyruvate, but maintained from glycerol, in liver perfusion of rats with early and late sepsis. CELL BIOCHEMISTRY AND FUNCTION (ONLINE), v.39, p.754-762, 2021.
QUINTILHANO, DÉBORA L.; MIKSZA, DANIELE R.; BIAZI, GIULIANA R.; FRASSON’UEMURA, ISABELE G.; GRACIANO, MARIA FERNANDA R.; MAZZUCO, TÂNIA L.; CARPINELLI, ÂNGELO R.; DE SOUZA, HELENIR M.; BERTOLINI, GISELE L. Effects of lixisenatide treatment on mild cachexia and related metabolic abnormalities in Walker-256 tumour-bearing rats. CELL BIOCHEMISTRY AND FUNCTION (ONLINE), v.39, p.335-343, 2020.
QUINTILHANO, DÉBORA LUIZA; MIKSZA, DANIELE ROMANI; DE SOUZA GALIA, WINNY BEATRIZ; RAMALHO, MAHIRA OLIVEIRA RAMALHO COSTA; LUCENA, CAMILA FERRAZ; VALLE, MAÍRA MELLO REZENDE; GRACIANO, MARIA FERNANDA RODRIGUES; DE SOUZA, HELENIR MEDRI; BERTOLINI, GISELE LOPES. Insulin secretion decline in Walker-256 tumor-bearing rats is early, follows the course of cachexia, and is not improved by lixisenatide. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v.Online, p.1-9, 2020.
FRASSON’UEMURA, ISABELE GONÇALVES; BIAZI, GIULIANA REGINA; MIKSZA, DANIELE ROMANI; MOREIRA, CAROLINA CAMPOS LIMA; CASSOLLA, PRISCILA; BERTOLINI, GISELE LOPES; BAZOTTE, ROBERTO BARBOSA; DE SOUZA, HELENIR MEDRI. Infusion of high concentration of lactate in perfused liver, simulating in vivo hyperlactatemia, prevents the reduction of gluconeogenesis in Walker-256 tumor-bearing rats. JOURNAL OF CELLULAR BIOCHEMISTRY, v.120, p.11068-11080, 2019.
BIAZI, GIULIANA R.; FRASSON, ISABELE G.; MIKSZA, DANIELE R.; DE MORAIS, HELY; DE FATIMA SILVA, FLAVIANE; BERTOLINI, GISELE L.; DE SOUZA, HELENIR M. Decreased hepatic response to glucagon, adrenergic agonists, and cAMP in glycogenolysis, gluconeogenesis, and glycolysis in tumor-bearing rats. JOURNAL OF CELLULAR BIOCHEMISTRY, v.119, p.7300-7309, 2018
Outras informações
Vice-coordenadora do Programa de Pós-Graduação em Ciências Fisiológicas