Laboratório de Fisiologia e Fisiopatologia Cardiovascular
martinspinge@uel.br
(43) 3371-5927Currículo
Currículo Lattes: http://lattes.cnpq.br/0791976490438294
Linha de Pesquisa
Fisiologia e Fisiopatologia cardiovascular
Descrição
O interesse do laboratório de fisiologia cardiovascular está em estudar os mecanismos de controle cardiocirculatório central e periférico em animais sob condições fisiológicas como o exercício físico e mudanças posturais, bem como em modelos animais de doenças como a obesidade, a sepse, a doença de Chagas e o parkinsonismo. Para essa abordagem utilizamos técnicas de estereotaxia; registro cardiovascular invasivo e não invasivo; análise da variabilidade cardiovascular e dosagens bioquímicas em plasma e tecidos.
Research description: The Cardiovascular Physiology Laboratory is interested in studying central and peripheral cardiocirculatory control mechanisms in animals under physiological conditions such as physical exercise and postural changes, as well as in animal models of diseases such as obesity, sepsis, Chagas disease, and parkinsonism. For this approach, we use techniques such as stereotaxy; invasive and non-invasive cardiovascular recording; analysis of cardiovascular variability; and biochemical assays in plasma and tissues.
Principais trabalhos
MARTINS-PINGE, M. C.; JAGER, L. ; CAMPOS, B. H. ; BEZERRA, L. O. ; TURINI, P. G. ; PINGE-FILHO, PHILENO . NITRIC OXIDE INVOLVEMENT IN CARDIOVASCULAR DYSFUNTIONS OF PARKINSON DISEASE. Frontiers in Pharmacology, v. 13, p. 898797, 2022.
LOPES, F. N. C. ; CUNHA, N. V. ; CAMPOS, B. H. ; FATTORI, V. ; PANIS, C. ; Cecchini R ; VERRI JUNIOR, W. ; PINGE-FILHO, PHILENO ; MARTINS-PINGE, M. C. . Antioxidant therapy reverses sympathetic dysfunction, oxidative stress, and hypertension in male hyperadipose rats. LIFE SCIENCES, v. 295, p. 120405, 2022.
RAQUEL, H. A. ; GUAZELLI, C. F. S. ; VERRI JR, W. A. ; Michelini LC ; MARTINS-PINGE, M. C. . Swimming training reduces iNOS expression, augments the antioxidant defense and reduces sympathetic responsiveness in the rostral ventrolateral medulla of normotensive male rats. BRAIN RESEARCH BULLETIN, v. 170, p. 225-233, 2021.
DE CAMPOS, BLENDA HYEDRA ; DE JAGER, LORENA ; REGINATO, GABRIELA SOUZA ; PEREIRA, RITO SANTO ; CRESTANI, Carlos César ; PINGE-FILHO, PHILENO ; MARTINS-PINGE, MARLI CARDOSO . Cardiovascular evaluation of female rats with 6-OHDA-induced parkinsonism: Possible protection by ovarian hormones and participation of nitric oxide. LIFE SCIENCES, v. 259, p. 118259, 2020.
TUROSSI AMORIM, ERIC DIEGO ; DE JAGER, LORENA ; MARTINS, ANDRESSA BUSETTI ; RODRIGUES, ANANDA TOTTI ; CRUZ LUCCHETTI, BRUNO FERNANDO ; ARIZA, DEBORAH ; PINGE’FILHO, PHILENO ; CRESTANI, Carlos Cesar ; UCHOA, ERNANE TORRES ; MARTINS’PINGE, MARLI CARDOSO . Glutamate and GABA neurotransmission are increased in paraventricular nucleus of hypothalamus in rats induced to 6-OHDA parkinsonism: Involvement of nNOS. ACTA PHYSIOLOGICA (ONLINE), v. 226, p. e13264, 2019.
LUCCHETTI, B. ; BOARETTO, N. ; LOPES, F. N. C. ; MALVEZI, A. D. ; LOVO-MARTINS, M. I. ; TATAKIHARA, V. ; FATTORI, V. ; PEREIRA, R. ; VERRI JUNIOR, W. ; ARAUJO, E. J. A. ; PINGE-FILHO, PHILENO ; MARTINS-PINGE, M. C. . Metabolic syndrome agravates cardiovascular, oxidative and inflammatory dysfunction during the acute phase of Trypanosoma cruzi infection in mice. Scientific Reports, v. 9, p. 18885, 2019.
DE JAGER, LORENA ; AMORIM, ERIC DIEGO TUROSSI ; LUCCHETTI, BRUNO FERNANDO CRUZ ; LOPES, FERNANDA NOVI CORTEGOSO ; CRESTANI, Carlos Cesar ; PINGE-FILHO, PHILENO ; MARTINS-PINGE, MARLI CARDOSO . Nitric oxide alterations in cardiovascular system of rats with Parkinsonism induced by 6-OHDA and submitted to previous exercise. LIFE SCIENCES, v. 204, p. 78-86, 2018.
RAQUEL, H. A. ; FERREIRA, N. Z. ; LUCCHETTI, B. ; BARNA, B. F. ; PINGE-FILHO, PHILENO ; Michelini LC ; MARTINS-PINGE, M. C. . The essential role of hypothalamic paraventricular nucleus nNOS in the modulation of autonomic control in exercised rats. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 79, p. 14-24, 2018.
PAULA, J. C. C. ; CAMPOS, B. H. ; JAGER, L. ; AMORIM, E. D. T. ; ZANLUQUI, N. ; FARIAS, C. C. ; HIGASHI, L. ; PINGE-FILHO, PHILENO ; BARBOSA, D. S. ; MARTINS-PINGE, M. C. . Effects of Inducible Nitric Oxide Synthase Inhibition on Cardiovascular Risk of Adult Endotoxemic Female Rats: Role of Estrogen. Frontiers in Physiology, v. 9, p. 1020, 2018.
CUNHA, N. V. ; LOPES, F. N. C. ; PANIS, C. ; Cecchini R ; PINGE-FILHO, PHILENO ; MARTINS-PINGE, M. C. . iNOS inhibition improves autonomic dysfunction and oxidative status in hypertensive obese rats. Clinical and Experimental Hypertension (1993, Print), v. 39, p. 50-57, 2017.
LUCCHETTI, B. ; ZANLUQUI, N. ; RAQUEL, H. A. ; LOVO-MARTINS, M. I. ; TATAKIHARA VL ; BELEM, M. O. ; Michelini LC ; ARAUJO, E. J. A. ; Pinge-Filho, P. ; MARTINS-PINGE, M. C. . Moderate treadmill exercise training improves cardiovascular and nitrergic response and resistance to Trypanosoma cruzi infection in mice. Frontiers in Physiology, v. 8, p. 315, 2017.
PAULA, J. C. C. ; CAMPOS, B. H. ; AMORIM, E. D. T. ; SILVA, R. V. ; FARIAS, C. C. ; HIGASHI, L. ; Pinge-Filho, P. ; BARBOSA, D. S. ; MARTINS-PINGE, M. C. . Cardiovascular risk and the effect of nitric oxide synthase inhibition in female rats: The role of estrogen. EXPERIMENTAL GERONTOLOGY, v. 97, p. 38-48, 2017.
RAQUEL, H. A. ; MASSON, G. S. ; BARNA, B. F. ; ZANLUQUI, N. ; PINGE-FILHO, PHILENO ; Michelini LC ; MARTINS-PINGE, M. C. . SWIMMING TRAINING MODULATES NITRIC OXIDE-GLUTAMATE INTERACTION IN THE ROSTRAL VENTROLATERAL MEDULLA IN NORMOTENSIVE CONSCIOUS RATS. Frontiers in Physiology, v. 7, p. 221, 2016.
ARIZA, D. ; SISDELI, L. ; CRESTANI, Carlos Cesar ; Fazan Jr., R ; MARTINS-PINGE, M. C. . DYSAUTONOMIAS IN PARKINSON’S DISEASE: CARDIOVASCULAR CHANGES AND AUTONOMIC MODULATION IN CONSCIOUS RATS AFTER INFUSION OF BILATERAL 6-OHDA IN SUBSTANTIA NIGRA. American Journal of Physiology. Heart and Circulatory Physiology, v. 308, p. H250-H257, 2015.
Silva, AS ; ARIZA, D. ; DIAS, Daniel P M ; CRESTANI, Carlos César ; MARTINS-PINGE, M. C. . Cardiovascular and autonomic alterations in rats with parkinsonism induced by 6-OHDA and treated with L-DOPA. Life Sciences (1973), v. 127, p. 82-89, 2015.
AMORIM, E. D. T. ; PERAS, V. R. ; ANDRADE, O. ; MARTINS-PINGE, M. C. . Functional evidence of paraventricular nucleus involvement in cardiovascular and autonomic modulation in response to acute microgravity (head-down tilt) in unanesthetized rats. Journal of Neuroscience Research, v. 93, p. 1305-1312, 2015.
Ariza, D ; LOPES, F. N. C. ; CRESTANI, Carlos Cesar ; MARTINS-PINGE, MARLI CARDOSO . CHEMOREFLEX AND BAROREFLEX ALTERATIONS IN PARKINSONISM INDUCED BY 6-OHDA IN UNANESTHETIZED RATS. Neuroscience Letters (Print), v. 607, p. 77-82, 2015.
CUNHA, N. V. ; Pinge-Filho, P. ; PANIS, C. ; SILVA, B. R. ; PERMONIAN, L. ; GRANDO, M. D. ; Cecchini R ; BENDHACK, L. M. ; MARTINS-PINGE, M. C. . DECREASED ENDOTHELIAL NITRIC OXIDE, SYSTEMIC OXIDATIVE STRESS AND INCREASED SYMPATHETIC MODULATION CONTRIBUTE TO HYPERTENSION IN OBESE RATS. American Journal of Physiology. Heart and Circulatory Physiology, v. 306, p. H1472-H1480, 2014.
de Andrade, Ozahyr ; BORGHI, SERGIO MARQUES ; de Souza, Hugo Celso Dutra ; Fontes, Marco Antonio Peliky ; MARTINS-PINGE, MARLI CARDOSO . Paraventricular nucleus of hypothalamus participates in the sympathetic modulation and spontaneous fluctuation of baroreflex during head up tilt in unanesthetized rats. Neuroscience Letters (Print), v. 558, p. 1-7, 2014.