{"id":754,"date":"2022-08-29T14:57:36","date_gmt":"2022-08-29T17:57:36","guid":{"rendered":"https:\/\/pos.uel.br\/pgcif\/?page_id=754"},"modified":"2025-06-06T09:36:41","modified_gmt":"2025-06-06T12:36:41","slug":"profa-dra-priscila-cassolla","status":"publish","type":"page","link":"https:\/\/pos.uel.br\/pgcif\/profa-dra-priscila-cassolla\/","title":{"rendered":"Profa. Dra. Priscila Cassolla"},"content":{"rendered":"\n
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Laborat\u00f3rio de Fisiologia Metab\u00f3lica<\/p>\n\n\n\n

Curr\u00edculo Lattes: http:\/\/lattes.cnpq.br\/3616815668290948<\/a><\/p>\n\n\n\n

ORCID: https:\/\/orcid.org\/0000-0001-6713-4079<\/a><\/p>\n\n\n\n

Linha de Pesquisa:<\/strong><\/p>\n\n\n\n

– Participa\u00e7\u00e3o do f\u00edgado na regula\u00e7\u00e3o da glicemia;<\/p>\n\n\n\n

– Altera\u00e7\u00f5es do metabolismo de carboidratos, lip\u00eddeos e prote\u00ednas em estados patol\u00f3gicos, como no diabetes tipo 2 e na caquexia associada ao c\u00e2ncer.<\/p>\n\n\n\n

Descri\u00e7\u00e3o da linha de pesquisa:<\/strong><\/p>\n\n\n\n

No Laborat\u00f3rio de Fisiologia Metab\u00f3lica investigamos a contribui\u00e7\u00e3o e regula\u00e7\u00e3o do metabolismo de glicose hep\u00e1tico (glic\u00f3lise, glicogen\u00f3lise e neoglicog\u00eanese) para a manuten\u00e7\u00e3o da glicemia em diferentes situa\u00e7\u00f5es, sejam fisiol\u00f3gicas ou patol\u00f3gicas, por meio da t\u00e9cnica de perfus\u00e3o de f\u00edgado in situ<\/em>. Estudamos tamb\u00e9m as altera\u00e7\u00f5es metab\u00f3licas em algumas doen\u00e7as, como na caquexia associada ao c\u00e2ncer (Walker-256) e no diabetes mellitus tipo 2 (ratos Goto-Kakizaki), pela avalia\u00e7\u00e3o de ganho de peso, ingest\u00e3o alimentar, dosagens bioqu\u00edmicas de par\u00e2metros metab\u00f3licos plasm\u00e1ticos, teste de toler\u00e2ncia \u00e0 glicose (GTT), teste de toler\u00e2ncia \u00e0 insulina (ITT), entre outros.<\/p>\n\n\n\n

Principais trabalhos publicados:<\/strong><\/p>\n\n\n\n

MIKSZA, DANIELE ROMANI; BIAZI, GIULIANA REGINA; FRASSON, ISABELE GON\u00c7ALVES; DE SOUZA GALIA, WINNY BEATRIZ; FERRAZ, LAURA SOCIO; DIAZ, BRENDA FRANCISCONI; KURAUTI, MIRIAN AYUMI; MARMENTINI, CARINE; MAREZE-COSTA, CEC\u00cdLIA EDNA; PERES, SIDNEY BARNAB\u00c9; CASSOLLA, PRISCILA; BERTOLINI, GISELE LOPES; BAZOTTE, ROBERTO BARBOSA; DE SOUZA, HELENIR MEDRI. Insulin in combination with pioglitazone prevents advanced cachexia in 256-Walker tumor-bearing rats: effect is greater than treatment alone and is associated with improved insulin sensitivity. Pharmacological Reports, v. 75, p. 1571-1587, 2023.<\/p>\n\n\n\n

DE MORAIS, HELY; B\u00d4AS, SU\u00c9LLEN KATHIANE FERNANDES VILAS; DE SOUZA, CAMILA OLIVEIRA; MIKSZA, DANIELE ROMANI; MOREIRA, CAROLINA C. L.; KURAUTI, MIRIAN AYUMI; SILVA, FLAVIANE DE F\u00c1TIMA; CASSOLLA, PRISCILA; SILVA, FRANCEMILSON GOULART DA; LIMIERE, LETICIA CRISTINA; GRASSIOLLI, SABRINA; BAZOTTE, ROBERTO BARBOSA; DE SOUZA, HELENIR MEDRI . Peripheral insulin resistance is early, progressive, and correlated with cachexia in Walker-256 tumor-bearing rats. Cell Biochemistry and Function, v. 5, p. 1-20, 2023.<\/p>\n\n\n\n


FRASSON\u2019UEMURA, ISABELE GON\u00c7ALVES; BIAZI, GIULIANA REGINA; MIKSZA, DANIELE ROMANI; MOREIRA, CAROLINA CAMPOS LIMA; CASSOLLA, PRISCILA; BERTOLINI, GISELE LOPES; BAZOTTE, ROBERTO BARBOSA; SOUZA, HELENIR MEDRI. Infusion of high concentration of lactate in perfused liver, simulating in vivo hyperlactatemia, prevents the reduction of gluconeogenesis in Walker-256 tumor-bearing rats. Journal of Cellular Biochemistry, v. 1, p. 1-13, 2019.<\/p>\n\n\n\n

DE FATIMA SILVA, FLAVIANE; ORTIZ-SILVA, MILENE; DE SOUZA GALIA, WINNY BEATRIZ; CASSOLLA, PRISCILA; GRACIANO, MARIA FERNANDA RODRIGUES; ZAIA, CASSIA THA\u00cfS BUSSAMRA VIEIRA; ZAIA, DIMAS; CARPINELLI, \u00c2NGELO RAFAEL; DA SILVA, FRANCEMILSON GOULART; DE SOUZA, HELENIR MEDRI. Pioglitazone improves insulin sensitivity and reduces weight loss in Walker-256 tumor-bearing rats. Life Sciences (1973), v. 171, p. 68-74, 2017.<\/p>\n\n\n\n

MOREIRA, CAROLINA CAMPOS LIMA; CASSOLLA, PRISCILA; DORNELLAS, ANA PAULA SEGANTINI; DE MORAIS, HELY; DE SOUZA, CAMILA OLIVEIRA; BORBA-MURAD, GLAUCIA REGINA; BAZOTTE, ROBERTO BARBOSA; DE SOUZA, HELENIR MEDRI. Changes in liver gluconeogenesis during the development of Walker-256 tumour in rats. International Journal of Experimental Pathology (Print), v. 94, p. 47-55, 2013.<\/p>\n\n\n\n

Redes sociais do laborat\u00f3rio ou outra que queira divulgar:<\/strong><\/p>\n\n\n\n

Instagram @muitobasicapraclinica<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Laborat\u00f3rio de Fisiologia Metab\u00f3lica Curr\u00edculo Lattes: http:\/\/lattes.cnpq.br\/3616815668290948 ORCID: https:\/\/orcid.org\/0000-0001-6713-4079 Linha de Pesquisa: – Participa\u00e7\u00e3o do f\u00edgado na regula\u00e7\u00e3o da glicemia; – Altera\u00e7\u00f5es do metabolismo de carboidratos, lip\u00eddeos e prote\u00ednas em estados patol\u00f3gicos, como no diabetes tipo 2 e na caquexia associada ao c\u00e2ncer. Descri\u00e7\u00e3o da linha de pesquisa: No Laborat\u00f3rio de Fisiologia Metab\u00f3lica investigamos a […]<\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-754","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/pages\/754","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/comments?post=754"}],"version-history":[{"count":6,"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/pages\/754\/revisions"}],"predecessor-version":[{"id":1679,"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/pages\/754\/revisions\/1679"}],"wp:attachment":[{"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/media?parent=754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}