{"id":563,"date":"2022-04-11T09:41:38","date_gmt":"2022-04-11T12:41:38","guid":{"rendered":"https:\/\/pos.uel.br\/pgcif\/?page_id=563"},"modified":"2025-06-06T09:09:39","modified_gmt":"2025-06-06T12:09:39","slug":"profa-dra-maria-fernanda-rodrigues-graciano","status":"publish","type":"page","link":"https:\/\/pos.uel.br\/pgcif\/profa-dra-maria-fernanda-rodrigues-graciano\/","title":{"rendered":"Profa. Dra.\u00a0Maria Fernanda Rodrigues Graciano"},"content":{"rendered":"\n
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<\/figcaption><\/figure>\n\n\n\n

Laborat\u00f3rio de Fisiologia do P\u00e2ncreas End\u00f3crino<\/p>\n\n\n\n

mafegraciano@uel.br<\/a><\/p>\n\n\n\n

(43) 3371-4201<\/p>\n\n\n\n

\u00a0Curr\u00edculo lattes:\u00a0http:\/\/lattes.cnpq.br\/4950119401164137<\/a><\/p>\n\n\n\n

ORCID: https:\/\/orcid.org\/0000-0001-8378-4063<\/a><\/a><\/p>\n\n\n\n

Linha de Pesquisa<\/em><\/strong><\/p>\n\n\n\n

Mecanismos fisiopatol\u00f3gicos que modulam a secre\u00e7\u00e3o de insulina e o controle glic\u00eamico.<\/p>\n\n\n\n

Descri\u00e7\u00e3o<\/em><\/strong><\/p>\n\n\n\n

O Laborat\u00f3rio de Fisiologia do P\u00e2ncreas End\u00f3crino investiga como diferentes processos fisiopatol\u00f3gicos, bem como a obesidade, o diabetes e a caquexia, podem modular a secre\u00e7\u00e3o de insulina pelas ilhotas pancre\u00e1ticas incubadas com diferentes secretagogos, a insulinemia, o controle glic\u00eamico e outros par\u00e2metros metab\u00f3licos em diferentes modelos experimentais em zebrafish e ratos.<\/p>\n\n\n\n

Principais trabalhos<\/strong><\/em><\/p>\n\n\n\n

QUINTILHANO, D. L.; MIKSZA, D. R.; DE SOUZA GALIA, W. B.; RAMALHO, M. O. R. C.; LUCENA, C. F.; VALLE, M. M. R.; GRACIANO, M. F. R.<\/strong>; DE SOUZA, H. M.;  BERTOLINI, G. L. Insulin secretion decline in Walker-256 tumor-bearing rats is early, follows the course of cachexia, and is not improved by lixisenatide. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v. 394, p. 697-705, 2021.<\/p>\n\n\n\n


FATIMA SILVA, F.; MORAIS, H.; ORTIZ SILVA, M. ; SILVA, F. G. ; VIANNA CROFFI, R.; SERRANO’NASCIMENTO, C.; RODRIGUES GRACIANO, M. F.<\/strong>; RAFAEL CARPINELLI, A.; BARBOSA BAZOTTE, R.; SOUZA, H. M. Akt activation by insulin treatment attenuates cachexia in Walker-256 tumor-bearing rats. JOURNAL OF CELLULAR BIOCHEMISTRY, v. 121(11), p.4558-4568, 2020.<\/p>\n\n\n\n


DE FATIMA SILVA, F.; ORTIZ-SILVA, M.; GALIA, W. B. S. ; CASSOLLA, P.; DA SILVA, F. G.; GRACIANO, M. F. R.<\/strong>; CARPINELLI, <\/a>A.; DE SOUZA, H. M. Effects of metformin on insulin resistance and metabolic disorders in tumor-bearing rats with advanced cachexia. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, v. 96, p. 498-505, 2018.<\/p>\n\n\n\n


DE FATIMA SILVA, F.; ORTIZ-SILVA, M.; DE SOUZA GALIA, W. B.; CASSOLLA, P.; GRACIANO, M. F. R.<\/strong>; ZAIA, C. T. B. V. ; ZAIA, D.; CARPINELLI, A. R.; DA SILVA, F. G.; DE SOUZA, H. M. Pioglitazone improves insulin sensitivity and reduces weight loss in Walker-256 tumor-bearing rats. Life Sciences (1973), v. 171, p. 68-74, 2017.<\/p>\n\n\n\n


GRACIANO, M. F.<\/strong><\/a> R.<\/strong>; LEONELLI, M. ; CURI, R. ; CARPINELLI, A.<\/a> R . Omega-3 fatty acids control productions of superoxide and nitrogen oxide and insulin content in INS-1E cells. Journal of Physiology and Biochemistry, v. 72, p. 699-710, 2016.<\/p>\n\n\n\n

GRACIANO, M. F.<\/strong><\/a> R.<\/strong>; VALLE, M. M.<\/a>; CURI, R. ; CARPINELLI, A. R<\/a>. Evidence for the involvement of GPR40 and NADPH oxidase in palmitic acid-induced superoxide production and insulin secretion. Islets (Print), v. 5, p. 139-148, 2013.<\/p>\n\n\n\n


GRACIANO, M. F.<\/strong><\/a> R.<\/strong>; SANTOS, L. R. B.<\/a> ; CURI, R.<\/a> ; CARPINELLI, A. R.<\/a> . NAD(P)H oxidase participates in the palmitate-induced superoxide production and insulin secretion by rat pancreatic islets. Journal of Cellular Physiology (Print), v. 226, p. 1110-1117, 2011.<\/p>\n","protected":false},"excerpt":{"rendered":"

Laborat\u00f3rio de Fisiologia do P\u00e2ncreas End\u00f3crino mafegraciano@uel.br (43) 3371-4201 \u00a0Curr\u00edculo lattes:\u00a0http:\/\/lattes.cnpq.br\/4950119401164137 ORCID: https:\/\/orcid.org\/0000-0001-8378-4063 Linha de Pesquisa Mecanismos fisiopatol\u00f3gicos que modulam a secre\u00e7\u00e3o de insulina e o controle glic\u00eamico. Descri\u00e7\u00e3o O Laborat\u00f3rio de Fisiologia do P\u00e2ncreas End\u00f3crino investiga como diferentes processos fisiopatol\u00f3gicos, bem como a obesidade, o diabetes e a caquexia, podem modular a secre\u00e7\u00e3o de […]<\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-563","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/pages\/563","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/comments?post=563"}],"version-history":[{"count":8,"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/pages\/563\/revisions"}],"predecessor-version":[{"id":1674,"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/pages\/563\/revisions\/1674"}],"wp:attachment":[{"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/media?parent=563"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}