{"id":546,"date":"2022-04-08T16:18:46","date_gmt":"2022-04-08T19:18:46","guid":{"rendered":"https:\/\/pos.uel.br\/pgcif\/?page_id=546"},"modified":"2022-04-08T16:18:46","modified_gmt":"2022-04-08T19:18:46","slug":"profa-dra-helenir-medri-de-souza","status":"publish","type":"page","link":"https:\/\/pos.uel.br\/pgcif\/profa-dra-helenir-medri-de-souza\/","title":{"rendered":"Profa. Dra. Helenir Medri de Souza"},"content":{"rendered":"\n<p>Laborat\u00f3rio de\u00a0Fisiologia Metab\u00f3lica<\/p>\n\n\n\n<p><br>Curr\u00edculo Lattes:<a href=\"http:\/\/buscatextual.cnpq.br\/buscatextual\/visualizacv.do?id=K4785281D7\"><\/a><\/p>\n\n\n\n<p><em><strong>Linha de Pesquisa<\/strong><\/em><\/p>\n\n\n\n<p>&#8211;&nbsp;&nbsp;Metabolismo hep\u00e1tico;<\/p>\n\n\n\n<p>&#8211;&nbsp;Participa\u00e7\u00e3o do f\u00edgado na regula\u00e7\u00e3o da glicemia;<\/p>\n\n\n\n<p>&#8211;&nbsp;&nbsp;&nbsp;Altera\u00e7\u00f5es do metabolismo de carboidratos, lip\u00eddeos e prote\u00ednas em estados patol\u00f3gicos, como na caquexia associada ao c\u00e2ncer (tumor Walker-256).<\/p>\n\n\n\n<p>&nbsp;<br><em><strong>Descri\u00e7\u00e3o<\/strong><\/em><\/p>\n\n\n\n<p>&#8211;&nbsp;Revis\u00e3o bibliogr\u00e1fica e semin\u00e1rios;<\/p>\n\n\n\n<p>&#8211;&nbsp;Treinamento t\u00e9cnico para manipula\u00e7\u00e3o de animais de laborat\u00f3rio (ratos);<\/p>\n\n\n\n<p>&#8211;&nbsp;&nbsp;Treinamento t\u00e9cnico para diversas dosagens bioqu\u00edmicas.<\/p>\n\n\n\n<p>&#8211;&nbsp;&nbsp;&nbsp;Experimentos de perfus\u00e3o de f\u00edgado&nbsp;<em>in situ<\/em>&nbsp;para avalia\u00e7\u00e3o da glicogen\u00f3lise, neoglicog\u00eanese e glic\u00f3lise;<\/p>\n\n\n\n<p>&#8211;&nbsp;&nbsp;Teste de toler\u00e2ncia \u00e0 insulina (ITT)<\/p>\n\n\n\n<p>&#8211;&nbsp;&nbsp;&nbsp;Teste de toler\u00e2ncia \u00e0 glicose (GTT);<\/p>\n\n\n\n<p>&#8211;&nbsp;&nbsp;Teste neoglicog\u00eanico (<em>in vivo<\/em>);<\/p>\n\n\n\n<p>&#8211;&nbsp;&nbsp;&nbsp;Manuten\u00e7\u00e3o de c\u00e9lulas tumorais Walker-256;<\/p>\n\n\n\n<p>&#8211;&nbsp;Desenvolvimento do tumor Walker-256 em ratos para o estabelecimento da anorexia-caquexia e altera\u00e7\u00f5es metab\u00f3licas associadas;<\/p>\n\n\n\n<p>&#8211;&nbsp;&nbsp;Avalia\u00e7\u00e3o do efeito de tratamentos sobre par\u00e2metros de anorexia-caquexia e de outras altera\u00e7\u00f5es metab\u00f3licas induzidas pelo Walker-256.<\/p>\n\n\n\n<p>&#8211;&nbsp;Treinamento t\u00e9cnico para confec\u00e7\u00e3o de gr\u00e1ficos e tabelas e an\u00e1lise estat\u00edstica dos resultados.<\/p>\n\n\n\n<p><em><strong>Principais trabalhos<\/strong><\/em><\/p>\n\n\n\n<p>-Trombini AB; Franco CC; Miranda RA; de Oliveira JC; Barella LF; Prates KV; de Souza AA; Pavanello A; Malta A; Almeida DL; T\u00f3folo LP; Rigo KP; Ribeiro TA; Fabricio GS; de Morais H; de Sant&#8217;Anna JR; Castro-Prado MA; DE SOUZA, HELENIR M.; Mathias PC.&nbsp;Early treatment with metformin induces resistance against tumor growth in adult rats.&nbsp;Cancer Biology &amp; Therapy, p. 1-7, 2015.<\/p>\n\n\n\n<p>-BASSOLI, Bruna Kempfer; Cassolla, Priscila; Borba-Murad, Glaucia Regina; CONSTANTIN, Jorgete; Salgueiro-Pagadigorria, Clairce Luzia; BAZOTTE, Roberto Barbosa; De Souza, Helenir Medri.&nbsp;Instant coffee extract with high chlorogenic acids content inhibits hepatic G-6-Pase in vitro, but does not reduce the glycaemia. Cell Biochemistry and Function, v. 1, p. n\/a-n\/a, 2015.<\/p>\n\n\n\n<p>-DE SOUZA, CAMILA OLIVEIRA; KURAUTI, MIRIAN AYUMI; DE FATIMA SILVA, FLAVIANE; DE MORAIS, HELY; CURI, Rui; HIRABARA, SANDRO MASSAO; ROSA NETO, JOS&#8217; CESAR; De Souza, Helenir Medri.&nbsp;Celecoxib and Ibuprofen Restore the ATP Content and the Gluconeogenesis Activity in the Liver of Walker-256 Tumor-Bearing Rats.&nbsp;Cellular Physiology and Biochemistry, v. 36, p. 1659-1669, 2015.<\/p>\n\n\n\n<p>-DA ROCHA, ALINE FRANCO; Liboni, Tha\u00eds Fernanda; KURAUTI, MIRIAN AYUMI; DE SOUZA, CAMILA OLIVEIRA; MIKSZA, DANIELE ROMANI; Moreira, Carolina Campos Lima; Borba-Murad, Glaucia Regina; BAZOTTE, Roberto Barbosa; De Souza, Helenir Medri.&nbsp;Tumor necrosis factor alpha abolished the suppressive effect of insulin on hepatic glucose production and glycogenolysis stimulated by cAMP.&nbsp;Pharmacological Reports, v. 66, p. 380-385, 2014.<\/p>\n\n\n\n<p>&#8211; SCHIAVON, FABIANA P.M.; MARQUES, ANY DE CASTRO RUIZ; CARRARA, MARCIA A.; De Souza, Helenir Medri; SCHAMBER, CHRISTIANO RODRIGUES; CURI, Rui; BAZOTTE, ROBERTO B. Pivotal role of cAMP in the activation of liver glycogen breakdown in high-fat diet fed mice.&nbsp;Life Sciences (1973), v. 1, p. 1-5, 2014.<\/p>\n\n\n\n<p>-FRANCO, CLAUDIN\u00c9IA CONATIONI DA SILVA; MIRANDA, ROSIANE APARECIDA; DE OLIVEIRA, J\u00daLIO CEZAR; BARELLA, LUIZ FELIPE; AGOSTINHO, ARYANE RODRIGUES; PRATES, KELLY VAL\u00c9RIO; MALTA, ANANDA; TROMBINI, AMANDA BIANCHI; TORREZAN, ROSANA; GRAVENA, CLARICE; T\u00d3FOLO, LAIZE P; DE SANT&#8217;ANNA, JULIANE ROCHA; DE CASTRO PRADO, MARIALBA AVEZUM ALVES; DE SOUZA, CAMILA OLIVEIRA; De Souza, Helenir Medri; BERALDI, EVANDRO JOS\u00c9; MATHIAS, PAULO CEZAR DE FREITAS.&nbsp;Protective effect of metformin against walker 256 tumor growth is not dependent on metabolism improvement. Cellular Physiology and Biochemistry (Online), v. 34, p. 1920-1932, 2014.<\/p>\n\n\n\n<p>-DE SOUZA, CAMILA OLIVEIRA; KURAUTI, MIRIAN AYUMI; DE FATIMA SILVA, FLAVIANE; DE MORAIS, HELY; Borba-Murad, Glaucia Regina; DE ANDRADE, F\u00c1BIO GOULART; De Souza, Helenir Medri.&nbsp;Effects of celecoxib and ibuprofen on metabolic disorders induced by Walker-256 tumor in rats.&nbsp;Molecular and Cellular&nbsp;Biochemistry, v. 399, p. 237-246, 2014.<\/p>\n\n\n\n<p>-Moreira, Carolina Campos Lima; Cassolla, Priscila; DORNELLAS, ANA PAULA SEGANTINI; DE MORAIS, HELY; DE SOUZA, CAMILA OLIVEIRA; Borba-Murad, Glaucia Regina; BAZOTTE, Roberto Barbosa; De Souza, Helenir Medri.&nbsp;Changes in liver gluconeogenesis during the development of Walker-256 tumour in rats.&nbsp;International Journal of Experimental Pathology (Print), v. 94, p. 47-55, 2013.<\/p>\n\n\n\n<p>-Rocha, AF; LIBONI, T. F.; Moreira, CCL; Miksza, D. R.; Souza, CO; Silva, F. F.; Borba-Murad, Glaucia Regina; BAZOTTE, R. B.; Souza, Helenir Medri.&nbsp;Inhibitory effect of tumor necrosis factor&nbsp;\u03b1&nbsp;on gluconeogenesis in perfused rat liver.&nbsp;Molecular and Cellular Biochemistry, v. 375, p. 89-96, 2013.<\/p>\n\n\n\n<p>&#8211; MIKSZA, DANIELE R.; DE SOUZA, CAMILA O; DE MORAIS, HELY; DA ROCHA, ALINE F.; BORBA-MURAD, GL\u00c1UCIA R.; BAZOTTE, ROBERTO B.; DE SOUZA, HELENIR M. Effect of infliximab on metabolic disorders induced by Walker-256 tumor in rats. Pharmacological Reports, v. 65, p. 960-969, 2013.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Laborat\u00f3rio de\u00a0Fisiologia Metab\u00f3lica Curr\u00edculo Lattes: Linha de Pesquisa &#8211;&nbsp;&nbsp;Metabolismo hep\u00e1tico; &#8211;&nbsp;Participa\u00e7\u00e3o do f\u00edgado na regula\u00e7\u00e3o da glicemia; &#8211;&nbsp;&nbsp;&nbsp;Altera\u00e7\u00f5es do metabolismo de carboidratos, lip\u00eddeos e prote\u00ednas em estados patol\u00f3gicos, como na caquexia associada ao c\u00e2ncer (tumor Walker-256). &nbsp;Descri\u00e7\u00e3o &#8211;&nbsp;Revis\u00e3o bibliogr\u00e1fica e semin\u00e1rios; &#8211;&nbsp;Treinamento t\u00e9cnico para manipula\u00e7\u00e3o de animais de laborat\u00f3rio (ratos); &#8211;&nbsp;&nbsp;Treinamento t\u00e9cnico para diversas dosagens [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-546","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/pages\/546","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/comments?post=546"}],"version-history":[{"count":1,"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/pages\/546\/revisions"}],"predecessor-version":[{"id":547,"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/pages\/546\/revisions\/547"}],"wp:attachment":[{"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/media?parent=546"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}