{"id":536,"date":"2022-04-08T16:04:13","date_gmt":"2022-04-08T19:04:13","guid":{"rendered":"https:\/\/pos.uel.br\/pgcif\/?page_id=536"},"modified":"2024-08-16T15:11:31","modified_gmt":"2024-08-16T18:11:31","slug":"profa-dra-gisele-lopes-bertolini-2","status":"publish","type":"page","link":"https:\/\/pos.uel.br\/pgcif\/profa-dra-gisele-lopes-bertolini-2\/","title":{"rendered":"Profa. Dra.\u00a0Gisele Lopes Bertolini"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

Laborat\u00f3rio de Fisiologia Metab\u00f3lica
giselebertolini@uel.br<\/a> <\/p>\n\n\n\n

(43) 3371-5942<\/p>\n\n\n\n

Curr\u00edculo Lattes: http:\/\/lattes.cnpq.br\/5587035486427002<\/a><\/a><\/p>\n\n\n\n

Linha de Pesquisa<\/em><\/strong><\/p>\n\n\n\n

Fisiologia Metab\u00f3lica<\/p>\n\n\n\n

Descri\u00e7\u00e3o<\/em><\/strong><\/p>\n\n\n\n

No Laborat\u00f3rio de Fisiologia Metab\u00f3lica estudamos a participa\u00e7\u00e3o do f\u00edgado na regula\u00e7\u00e3o da glicemia e do metabolismo energ\u00e9tico em diferentes condi\u00e7\u00f5es metab\u00f3licas. Estudamos tamb\u00e9m as altera\u00e7\u00f5es do metabolismo de carboidratos, lip\u00eddeos e prote\u00ednas em diferentes estados patol\u00f3gicos, como no diabetes mellitus<\/em>.<\/p>\n\n\n\n

Research description:<\/strong>nIn the Metabolic Physiology Laboratory, we study the liver’s role in regulating blood glucose levels and energy metabolism under various metabolic conditions. We also investigate changes in carbohydrate, lipid, and protein metabolism in different pathological states, such as diabetes mellitus.<\/em><\/p>\n\n\n\n

Principais trabalhos<\/em><\/strong><\/p>\n\n\n\n

MIKSZA, DANIELE ROMANI ; BIAZI, GIULIANA REGINA ; FRASSON, ISABELE GON\u00c7ALVES ; DE SOUZA GALIA, WINNY BEATRIZ ; FERRAZ, LAURA SOCIO ; DIAZ, BRENDA FRANCISCONI ; KURAUTI, MIRIAN AYUMI ; MARMENTINI, CARINE ; MAREZE-COSTA, CEC\u00cdLIA EDNA ; PERES, SIDNEY BARNAB\u00c9 ; CASSOLLA, PRISCILA ; BERTOLINI, GISELE LOPES ; BAZOTTE, ROBERTO BARBOSA ; DE SOUZA, HELENIR MEDRI . Insulin in combination with pioglitazone prevents advanced cachexia in 256-Walker tumor-bearing rats: effect is greater than treatment alone and is associated with improved insulin sensitivity. Pharmacological Reports, v. 75, p. 1571-1587, 2023.<\/p>\n\n\n\n

BIAZI, GIULIANA R. ; UEMURA, ISABELE G. F. ; MIKSZA, DANIELE R. ; FERRAZ, LAURA S. ; DIAZ, BRENDA F. ; BERTOLINI, GISELE L. ; DE SOUZA, HELENIR M. . Interleukin 6 acutely increases gluconeogenesis and decreases the suppressive effect of insulin on cAMP-stimulated glycogenolysis in rat liver. CELL BIOCHEMISTRY AND FUNCTION, v. 41, p. 609-618, 2023.<\/p>\n\n\n\n

SOUZA GALIA, WINNY BEATRIZ; BIAZI, GIULIANA REGINA; FRASSON’UEMURA, ISABELE GON\u00c7ALVES; MIKSZA, DANIELE ROMANI; ZAIA, C\u00c1SSIA THA\u00cfS BUSSAMRA VIEIRA; ZAIA, DIMAS AUGUSTO MOROZIN; SOUZA, HELENIR MEDRI; BERTOLINI, GISELE LOPES. Gluconeogenesis is reduced from alanine, lactate and pyruvate, but maintained from glycerol, in liver perfusion of rats with early and late sepsis. CELL BIOCHEMISTRY AND FUNCTION (ONLINE), v.39, p.754-762, 2021.<\/p>\n\n\n\n

QUINTILHANO, D\u00c9BORA L.; MIKSZA, DANIELE R.; BIAZI, GIULIANA R.; FRASSON’UEMURA, ISABELE G.; GRACIANO, MARIA FERNANDA R.; MAZZUCO, T\u00c2NIA L.; CARPINELLI, \u00c2NGELO R.; DE SOUZA, HELENIR M.; BERTOLINI, GISELE L. Effects of lixisenatide treatment on mild cachexia and related metabolic abnormalities in Walker-256 tumour-bearing rats. CELL BIOCHEMISTRY AND FUNCTION (ONLINE), v.39, p.335-343, 2020.<\/p>\n\n\n\n

QUINTILHANO, D\u00c9BORA LUIZA; MIKSZA, DANIELE ROMANI; DE SOUZA GALIA, WINNY BEATRIZ; RAMALHO, MAHIRA OLIVEIRA RAMALHO COSTA; LUCENA, CAMILA FERRAZ; VALLE, MA\u00cdRA MELLO REZENDE; GRACIANO, MARIA FERNANDA RODRIGUES; DE SOUZA, HELENIR MEDRI; BERTOLINI, GISELE LOPES. Insulin secretion decline in Walker-256 tumor-bearing rats is early, follows the course of cachexia, and is not improved by lixisenatide. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v.Online, p.1-9, 2020.<\/p>\n\n\n\n

FRASSON’UEMURA, ISABELE GON\u00c7ALVES; BIAZI, GIULIANA REGINA; MIKSZA, DANIELE ROMANI; MOREIRA, CAROLINA CAMPOS LIMA; CASSOLLA, PRISCILA; BERTOLINI, GISELE LOPES; BAZOTTE, ROBERTO BARBOSA; DE SOUZA, HELENIR MEDRI. Infusion of high concentration of lactate in perfused liver, simulating in vivo hyperlactatemia, prevents the reduction of gluconeogenesis in Walker-256 tumor-bearing rats. JOURNAL OF CELLULAR BIOCHEMISTRY, v.120, p.11068-11080, 2019. <\/p>\n\n\n\n

BIAZI, GIULIANA R.; FRASSON, ISABELE G.; MIKSZA, DANIELE R.; DE MORAIS, HELY; DE FATIMA SILVA, FLAVIANE; BERTOLINI, GISELE L.; DE SOUZA, HELENIR M. Decreased hepatic response to glucagon, adrenergic agonists, and cAMP in glycogenolysis, gluconeogenesis, and glycolysis in tumor-bearing rats. JOURNAL OF CELLULAR BIOCHEMISTRY, v.119, p.7300-7309, 2018<\/p>\n\n\n\n

Outras informa\u00e7\u00f5es<\/strong><\/p>\n\n\n\n

Vice-coordenadora do Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Fisiol\u00f3gicas <\/p>\n","protected":false},"excerpt":{"rendered":"

Laborat\u00f3rio de Fisiologia Metab\u00f3licagiselebertolini@uel.br (43) 3371-5942 Curr\u00edculo Lattes: http:\/\/lattes.cnpq.br\/5587035486427002 Linha de Pesquisa Fisiologia Metab\u00f3lica Descri\u00e7\u00e3o No Laborat\u00f3rio de Fisiologia Metab\u00f3lica estudamos a participa\u00e7\u00e3o do f\u00edgado na regula\u00e7\u00e3o da glicemia e do metabolismo energ\u00e9tico em diferentes condi\u00e7\u00f5es metab\u00f3licas. Estudamos tamb\u00e9m as altera\u00e7\u00f5es do metabolismo de carboidratos, lip\u00eddeos e prote\u00ednas em diferentes estados patol\u00f3gicos, como no diabetes […]<\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-536","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/pages\/536","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/comments?post=536"}],"version-history":[{"count":7,"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/pages\/536\/revisions"}],"predecessor-version":[{"id":1344,"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/pages\/536\/revisions\/1344"}],"wp:attachment":[{"href":"https:\/\/pos.uel.br\/pgcif\/wp-json\/wp\/v2\/media?parent=536"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}